TABLE 35-4
Human Cytokines (Interleukins, Interferons, Other Cytokines)
(continued)
Name
Mol Wt
kDA
Sources
Effects on Cells
Interferons
Interferon
19.2
Virally infected cells
Participates in the innate immune response, induces resistance to viral
a
2 0
RNA synthesis
P
16.7
Antigen-stimulated cells,
Ï
Other
Cytokines
NK cells in response to IL-1
orTNF
Expression of MHC I & II, T cell differentiation, synthesis of IgG2,
antagonizes IL-4 action
TNFa
17
Macrophages, NK cells, B cells,
T cells, mast cells
Activates monocytes, PMN cells, promotes inflammation
TNF/3
lymphotoxin
18.6
Thl cells, B cells,
Cytotoxic, promotes inflammation, can inhibit T cell activation
TGF/3
5.5
T cells, B cells,
macrophages, mast cells
Immunosuppressive
GM-CSF
14
T cells, macrophages, B cells,
mast cells
Promotes growth of granulocytes and monocytes
